COTRIMOXAZOLE DS (JOLLY) – 10 TABLETS

COTRIMOXAZOLE is a combination antibiotic containing Trimethoprim and Sulphamethoxazole. Trimethoprim inhibits bacterial folate synthesis, while Sulphamethoxazole blocks a different step in the same pathway. Together, they provide a synergistic effect that targets a broad spectrum of bacteria. This medication is prescribed for treating infections such as urinary tract infections (UTIs), bronchitis, and travelers’ diarrhea. COTRIMOXAZOLE is known for its effectiveness against resistant bacterial strains due to this combined approach.

Usage Instructions

1. Consult Your Doctor: Confirm that COTRIMOXAZOLE is suitable for your condition.
2. Follow Dosage Guidelines: Take one tablet every 12 hours as prescribed by your healthcare provider.
3. Take with Food: To minimize stomach upset, take the tablet with or just after meals.
4. Complete the Course: Finish the entire course of medication even if you feel better before the end.
5. Drink Plenty of Water: Stay hydrated to help your body fight the infection and reduce potential side effects.

Medicinal Advantages

COTRIMOXAZOLE offers several medicinal advantages:

• Broad-Spectrum Antibiotic: Combines Trimethoprim and Sulphamethoxazole to effectively target a wide range of bacterial pathogens.
• Synergistic Action: The combination enhances effectiveness against bacteria that are resistant to other antibiotics.
• Versatile Treatment: Effective for various infections including UTIs, respiratory infections, and gastrointestinal conditions.
• Proven Efficacy: Clinically proven to manage infections that may not respond to single-agent antibiotics.

Mechanism of Action

COTRIMOXAZOLE works through a dual-mechanism approach:

• Trimethoprim: Inhibits dihydrofolate reductase, an enzyme essential for bacterial folate synthesis.
• Sulphamethoxazole: Inhibits dihydropteroate synthase, another enzyme required for bacterial folate synthesis.

By blocking two critical steps in the folate biosynthesis pathway, COTRIMOXAZOLE effectively disrupts bacterial DNA synthesis, leading to bacterial cell death.

Off-Label Uses

COTRIMOXAZOLE may also be used off-label for:

• Pneumocystis jirovecii Pneumonia (PCP): Used as a treatment for PCP in immunocompromised patients.
• Chronic Bronchitis: Sometimes used for chronic bronchitis exacerbations not responsive to other antibiotics.
• Toxoplasmosis: Can be used for the treatment of Toxoplasma infections in combination with other drugs.

Expert Advice

To maximize the effectiveness of COTRIMOXAZOLE:

• Follow Your Doctor’s Instructions: Adhere to the prescribed dosage and duration for the best outcomes.
• Complete the Full Course: Do not stop taking the medication early, even if you start feeling better.
• Hydrate Well: Drink plenty of fluids to help the medication work effectively and reduce side effects.

Precautions

1. Allergic Reactions: Avoid use if you have a known allergy to sulfonamides or Trimethoprim.
   • Explanation: Allergic reactions can cause severe symptoms like rash, fever, or difficulty breathing.
2. Kidney Function: Use cautiously if you have impaired kidney function.
   • Explanation: COTRIMOXAZOLE is excreted through the kidneys, and impaired function can increase the risk of side effects.
3. Pregnancy and Breastfeeding: Consult a healthcare provider if you are pregnant or breastfeeding.
   • Explanation: COTRIMOXAZOLE may not be suitable during pregnancy or breastfeeding due to potential risks.

Storage Conditions

Store COTRIMOXAZOLE at room temperature, between 68°F and 77°F (20°C to 25°C). Keep in a dry place, away from direct sunlight and moisture. Ensure the medication is kept out of reach of children.

FAQs

Q1. What is COTRIMOXAZOLE used for?
COTRIMOXAZOLE is used to treat various bacterial infections including UTIs, respiratory infections, and gastrointestinal infections.

Q2. How should I take COTRIMOXAZOLE?
Take one tablet every 12 hours with food or just after meals, as directed by your healthcare provider. Complete the full course.

Q3. How long does it take for COTRIMOXAZOLE to work?
You may start to feel better within a few days, but continue the medication for the full prescribed duration.

Q4. Can I drink alcohol while taking COTRIMOXAZOLE?
Moderate alcohol consumption is generally acceptable, but excessive alcohol can increase side effects and affect your recovery.

Q5. Can I take COTRIMOXAZOLE with other medications?
Inform your healthcare provider of all other medications you are taking to avoid interactions.