COMBIGAN – 1 BOTTLE OF 5ML

COMBIGAN Ophthalmic Solution offers an effective treatment for patients with glaucoma or ocular hypertension by combining two active ingredients: Timolol, a beta-blocker that reduces fluid production in the eye, and Brimonidine, an alpha agonist that increases fluid drainage. This dual-action approach helps to significantly lower IOP, thereby reducing the risk of optic nerve damage and preserving vision. COMBIGAN is suitable for those who require more than one medication to control their IOP.

Usage Instructions:
Prepare: Wash your hands thoroughly before application.
Instill Drops: Tilt your head back and gently pull down your lower eyelid to create a pocket. Hold the dropper above the eye and squeeze gently to release one drop.
Close Eyes: Close your eyes and press gently on the inner corner of your eye for about 1 minute to prevent the solution from draining into the tear duct.
Repeat: Apply in the other eye if directed by your doctor. Use twice daily, about 12 hours apart, or as prescribed by your healthcare provider.

Medicinal Advantages:
Lowering IOP: Effectively reduces intraocular pressure in glaucoma and ocular hypertension patients.
Dual Action: Combines two mechanisms to both reduce fluid production and increase fluid outflow in the eye.
Vision Preservation: Helps prevent optic nerve damage and vision loss associated with high IOP.

Mechanism of Action:
COMBIGAN Ophthalmic Solution works by combining the effects of Timolol and Brimonidine. Timolol reduces the production of aqueous humor (fluid in the eye), while Brimonidine increases the drainage of this fluid through the eye’s natural filtration system. The result is a significant reduction in intraocular pressure, protecting the optic nerve from damage and preventing the progression of glaucoma.

Off-Label Uses:
COMBIGAN may be used off-label in certain cases to manage elevated IOP in patients with normal-tension glaucoma or for patients who are intolerant to prostaglandin analogs.

Expert Advice:
Adherence: Use COMBIGAN as prescribed without missing doses to maintain stable IOP.
Monitor Pressure: Regularly monitor your intraocular pressure as advised by your doctor.
Avoid Contamination: Ensure the dropper tip does not touch any surface, including the eye, to avoid contamination.

Precautions:
Breathing Issues: If you have asthma or other respiratory conditions, consult your doctor before using COMBIGAN, as Timolol may cause breathing difficulties.
Heart Conditions: Patients with heart disease should use COMBIGAN with caution due to the beta-blocker component, which may affect heart rate and blood pressure.
Allergic Reactions: Watch for signs of an allergic reaction, such as itching, swelling, or severe irritation, and discontinue use if symptoms occur.

Storage Conditions:
Temperature: Store at room temperature, away from direct light and heat.
Keep Container Closed: Ensure the bottle is tightly closed when not in use.
Shelf Life: Use before the expiration date indicated on the packaging. Discard any unused solution after this date.

FAQs:
Q: What is COMBIGAN Ophthalmic Solution used for?
A: COMBIGAN is used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
Q: How does COMBIGAN work?
A: It combines Timolol, which reduces fluid production in the eye, and Brimonidine, which increases fluid drainage, to effectively lower eye pressure.
Q: How often should I use COMBIGAN?
A: Typically, COMBIGAN is used twice daily, approximately 12 hours apart, or as directed by your doctor.
Q: Can I use COMBIGAN with contact lenses?
A: Remove contact lenses before applying COMBIGAN. Wait at least 15 minutes before reinserting them.
Q: Can COMBIGAN cause any breathing problems?
A: Yes, COMBIGAN may cause breathing difficulties, especially in patients with asthma or other respiratory conditions. Consult your doctor if you have any concerns.